When the packets began making their way to Port Blair, those hailing from the mainland of India recognized that they contained narcotic drugs.
The vehicle of the duo, both residents of Anthikad, was followed and then stopped by the police based on a tip-off.
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The NCB claimed to have busted a pan-India drugs trafficking network operating on the dark web with the seizure of 15,000 LSD blots in one operation.
The Union Home Minister said that during ten years of UPA, narcotics worth Rs 680 crore were seized.
According to NCB sources, the drugs were traced to a Pakistan-based mafia led by Haji Salim.
The accused has reportedly told the authorities that the cargo had more than twice the quantity seized.
There are also unconfirmed reports that the 2,525kg crystal meth was only a part of the real seizure.
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A suspected Pakistani national has been detained.